NDLI: In vivo and In vitro Differences in the Charge-injection and Electrochemical Properties of Iridium Oxide Electrodes

Content Provider	IEEE Xplore Digital Library
Author	Cogan, S.F.
Copyright Year	2006
Description	Author affiliation: EIC Labs. Inc., Norwood, MA (Cogan, S.F.)
Abstract	The electrochemical response of activated iridium oxide (AIROF) electrodes implanted acutely in the subretinal space of the rabbit is compared with in vitro measurements in model electrolytes. Voltage transients during current pulsing, cyclic voltammetry, impedance spectroscopy and open-circuit potential measurements were compared. Subretinal charge injection by constant current pulsing required significantly greater driving voltages due to both higher access resistances (iR) and large electrochemical polarization across the electrode-tissue interface. Differences in the in vivo and in vitro open-circuit potentials were also noted. The data suggest that the buffering capacity in the subretinal space, at least in the acute study, is higher than that in inorganic models of interstitial fluid. Possible origins of these differences in terms of electrode-tissue interactions are discussed
Sponsorship	IEEE EMB
Starting Page	882
Ending Page	885
File Size	315167
Page Count	4
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.259654
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vivo In vitro Electrodes Electrical resistance measurement Voltage Rabbits Electrochemical impedance spectroscopy Current measurement Impedance measurement Polarization
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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