NDLI: Association between pathways in regulatory networks

Content Provider	IEEE Xplore Digital Library
Author	Kluger, Y. Kluger, H. Tuck, D.
Copyright Year	2006
Description	Author affiliation: Dept. of Cell Biol., New York Univ. Sch. of Medicine, NY (Kluger, Y.)
Abstract	During cell progression from one state to another, such as transformation from benign to malignant conditions, cells undergo changes in gene regulation. To reveal state-dependent circuitries in human regulatory networks, we employed drafts of normal and malignant cell networks. Using these condition specific networks, gene profiles and annotated pathways we studied: a) the capacity to separate samples or cell states based on the collective expression of all the genes in each pathway rather than individual genes, b) the degree of regulatory network connectivity within and between pathways. Distinct cell types reveal notable differences in transcriptional activity in numerous pathways. On the other hand, in datasets from breast cancer patients with variable outcome the capacity of single pathway expression signatures to predict disease outcome is very limited, though this can be somewhat improved by combining multiple pathways. Remarkable connectivity between pathways on the transcriptional regulatory level revealed a non-modular network structure. Overall, network blueprints enable us to quantify the degree of interaction between condition specific co-regulated pathways. This can contribute to understanding deregulated processes associated with cancer
Sponsorship	IEEE EMB
Starting Page	2036
Ending Page	2040
File Size	299993
Page Count	5
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.260730
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gene expression Humans Breast neoplasms Breast cancer Cities and towns USA Councils Biological materials Production Mice Embryo
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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