NDLI: Suppression of Neural Activity with High Frequency Stimulation

Content Provider	IEEE Xplore Digital Library
Author	Durand, D.M. Jensen, A. Bikson, M.
Copyright Year	2006
Description	Author affiliation: Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH (Durand, D.M.; Jensen, A.)
Abstract	Deep brain stimulation (DBS) has been shown to generate suppression of abnormal neural activity in patients with Parkinson's disease and epilepsy. High frequency stimulation is applied to the brain through depth electrodes in the range of 50 to 200 Hz. Yet the mechanisms underlying the suppression effect have not yet been elucidated. In order to study directly the effect of HFS in the brain, sinusoidal stimulation was applied in the in-vitro brain slice preparation. Sinusoidal stimulation was chosen in order to observe the activity during the stimulation by filtering the stimulation artifact. Sinusoidal stimulation at 50 Hz applied to the CA1 region of the hippocampus was observed to block epileptiform activity in three separate models of epilepsy induced by low-calcium, high potassium and picrotoxin $(GABA_{A}$ blocker). Stimulation applied to the alveus showed that activity in both the cell bodies (evoked potentials) and in the axons (compound action potentials) is suppressed. The frequency range of this effect is nearly identical to that of DBS with maximum suppression effect between 50 and 200 Hz. The effect could not be attributed to desynchronization or damage and was associated with increased extracellular potassium concentrations. These data provide new insights into the effects of HFS on neuronal elements and show that HFS can block axonal activity through non-synaptic mechanisms
Sponsorship	IEEE EMB
Starting Page	1624
Ending Page	1625
File Size	255694
Page Count	2
File Format	PDF
ISBN	1424400325
ISSN	1557170X
DOI	10.1109/IEMBS.2006.259396
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Frequency Epilepsy Satellite broadcasting Brain stimulation Parkinson's disease Electrodes In vitro Filtering Hippocampus Nerve fibers Electrical Stimulation Suppression of neural activity
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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