NDLI: A computational model for bipolar deep brain stimulation of the subthalamic nucleus

Content Provider	IEEE Xplore Digital Library
Author	Iacono, M.I. Neufeld, E. Bonmassar, G. Akinnagbe, E. Jakab, A. Cohen, E. Kuster, N. Kainz, W. Angelone, L.M.
Copyright Year	2014
Description	Author affiliation: Found. for Res. on Inf. Technol. in Soc. (IT'IS), Zurich, Switzerland (Neufeld, E.; Kuster, N.) \|\| Center for Devices & Radiol. Health, U.S. Food & Drug Adm., Silver Spring, MD, USA (Iacono, M.I.; Akinnagbe, E.; Cohen, E.; Kainz, W.; Angelone, L.M.) \|\| Comput. Image Anal. & Radiol. Lab., Med. Univ. of Vienna, Vienna, Austria (Jakab, A.) \|\| Dept. of Radiol., Center for Biomed. Imaging, Charlestown, MA, USA (Bonmassar, G.)
Abstract	Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to reduce some of the symptoms of advanced, levodopa-responsive Parkinson's disease that are not adequately controlled with medication. However, the precise mechanism of the therapeutic action of DBS is still unclear. Stimulation-induced side effects are not uncommon and require electrical “dose” adjustments. Quantitative methods are needed to fully characterize the electric field in the deep brain region that surrounds the electrodes in order to help with adjustments and maximize the efficacy of the device. Herein we report a magnetic resonance imaging (MRI)-based head model proposed for analysis of fields generated by deep brain stimulation (DBS). The model was derived from multimodal image data at 0.5mm isotropic spatial resolution and distinguishes 142 anatomical structures, including the basal ganglia and 38 nuclei of the thalamus. Six bipolar electrode configurations (1-2, 1-3, 1-4, 2-3, 2-4, 3-4) were modeled in order to assess the effects of the inter-electrode distance of the electric field. Increasing the distance between the electrodes results in an attenuated stimulation, with up to 25% reduction in electric field amplitude delivered (2-3 vs. 1-4). The map of the deep brain structures provided a highly precise anatomical detail which is useful for the quantitative assessment of current spread around the electrode and a better evaluation of the stimulation setting for the treatment optimization.
Sponsorship	IEEE Eng. Med. Biol. Soc.
Starting Page	6258
Ending Page	6261
File Size	1082175
Page Count	4
File Format	PDF
ISBN	9781424479290
ISSN	1557170X
DOI	10.1109/EMBC.2014.6945059
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-08-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric fields Satellite broadcasting Electrodes Brain modeling Biological system modeling Head Magnetic resonance imaging
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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