NDLI: Regulatory network of microRNAs in RAW 264.7 macrophage cells

Content Provider	IEEE Xplore Digital Library
Author	Garmire, L.X. ZhouXin Shen Briggs, S. Gene Yeo Subramaniam, S. Glass, C.
Copyright Year	2010
Description	Author affiliation: Bioengineering Department of UC-San Diego, La Jolla, USA (Garmire, L.X.; Subramaniam, S.) \|\| Cellular & Molecular Medicine Department of UC-San Diego, La Jolla, USA (Gene Yeo; Glass, C.) \|\| Division of Biosciences, UC-San Diego, La Jolla, USA (ZhouXin Shen; Briggs, S.)
Abstract	microRNAs (miRNA) play important roles in regulating immunity. Here we utilize the systems biology approach to predict the regulatory network of miRNAs among the most down-regulated genes by the lipopolysaccharides (LPS) treatment in the macrophage RAW267.4 cell line. We combine the proteome and transcriptome data sets to define 200 target genes that are significantly down-regulated by the LPS treatment. We perform the profiling of over 300 miRNAs with the RNA-Seq method. Using the complementary binding rule between the seed sequences of profiled miRNAs and the 3'UTRs of target genes, we predict genes involved in mobility, metabolism, and oxidative phosphorylation as the top targets of miRNA negative regulation.
Starting Page	6198
Ending Page	6201
File Size	467076
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5627742
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Immune system Diseases Probes Genomics Bioinformatics RNA
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Modeling breast cell cycle regulation - overcoming drug resistance

Building phylogenetic trees by using gene Nucleotide Genomic Signals

A novel genome-wide polyadenylation sites recognition system based on condition random field

A hybrid framework for genome wide epistasis discovery

Multi-scale modeling of gene regulatory networks via integration of temporal and topological biological data

SNP analysis of Rac1 For personalized ligand interaction

Computer Assisted Detection of Cancer Cells in Minimal Samples of Lung Cancer

Benchmarking RNA-Seq quantification tools

"Computational Biology and Bioinformatics"

Regulatory network of microRNAs in RAW 264.7 macrophage cells

Similar Documents

Modeling breast cell cycle regulation - overcoming drug resistance

Building phylogenetic trees by using gene Nucleotide Genomic Signals

A novel genome-wide polyadenylation sites recognition system based on condition random field

A hybrid framework for genome wide epistasis discovery

Multi-scale modeling of gene regulatory networks via integration of temporal and topological biological data

SNP analysis of Rac1 For personalized ligand interaction

Computer Assisted Detection of Cancer Cells in Minimal Samples of Lung Cancer

Benchmarking RNA-Seq quantification tools

"Computational Biology and Bioinformatics"

Regulatory network of microRNAs in RAW 264.7 macrophage cells