NDLI: Noninvasive Assessment of Cardiovascular Autonomic Control in Pediatric Obstructive Sleep Apnea Syndrome

Content Provider	IEEE Xplore Digital Library
Author	Zheng Lin Chen, M.L. Keens, T.G. Davidson Ward, S.L. Khoo, M.C.K.
Copyright Year	2005
Description	Author affiliation: Dept. of Biomed. Eng., Southern California Univ., Los Angeles, CA (Zheng Lin)
Abstract	Studies suggest that obstructive sleep apnea syndrome (OSAS) is causally related to abnormal cardiovascular autonomic control in adults, but this has not been established in pediatric OSAS. The goal of this study was to quantify autonomic system dysfunction, as manifested by cardiovascular response abnormalities, in children with OSAS. During wakefulness, we continuously measured the ECG, arterial blood pressure and airflow in each subject. These measurements were made during the following conditions: spontaneous breathing in the supine posture (baseline), spontaneous breathing in the standing posture (orthostatic stress); tracking of the subject's own prior spontaneous breathing pattern while supine (mental stress), and during a cold face challenge. Using spectral analysis and modeling techniques, we sought to computationally delineate the physiological mechanisms that mediate these abnormalities. Our preliminary results suggest that the autonomic effects of pediatric OSAS differ from those in adult in that parasympathetic activity remains relatively normal despite the elevated peripheral sympathetic drive
Starting Page	776
Ending Page	779
File Size	260377
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616530
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cardiology Sleep apnea Rail to rail inputs Mathematical model Biomedical monitoring Fluctuations Density estimation robust algorithm Pediatrics Biomedical engineering USA Councils
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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