NDLI: Experimental Study on Ultrasonic Thermal Chemotherapy for Tumor Treatment

Content Provider	IEEE Xplore Digital Library
Author	Jingfbai Bai Guoxin Ren Yazhu Chen Wei Guo
Copyright Year	2005
Description	Author affiliation: Biomed. Instrum. Inst., Shanghai Jiao Tong Univ. (Jingfbai Bai; Guoxin Ren; Yazhu Chen)
Abstract	Ultrasound thermal chemotherapy (UTC) method was used to investigate the mechanism of apoptosis of tumor cells induced by ultrasound thermal therapy combined with thermosensitive drug in mice tumor model (MTM). And the optimal parameters of ultrasonic, such as frequency, dose, sound field, treatment time and temperature, were found by the animal trials which the Tca8113 cells had been inoculated into the body of nude mice. Experimental results showed that the optimized thermal treatment technology of ultrasonic combined with the chemotherapy could produce obvious inhibitory effects of the tumor's growth. We also found that apoptosis reached its highest levels in the 6th to 10th hour, then gradually decreased and nearly resumed the normal level after the $12^{th}$ hour. UTC method could induce tumor cells to die significantly
Starting Page	6781
Ending Page	6784
File Size	519355
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616061
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neoplasms Ultrasonic imaging Tumors Mice Medical treatment Drugs Frequency Temperature Animals Chemical technology
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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