NDLI: The Effects of κ-Opioid Receptor Stimulation on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart

Content Provider	IEEE Xplore Digital Library
Author	Bao-ping Chen Fang-yan Fan Guang-yuan Ren Jing-shun Jin Hong-jiao Mao Li-ping Wu Bruce, I.C. Qiang Xia
Copyright Year	2005
Description	Author affiliation: Dept. of Physiol., Zhejiang Univ. Sch. of Med., Hangzhou (Bao-ping Chen; Fang-yan Fan)
Abstract	Two series of experiments were performed in the perfused isolated rat heart to determine whether stimulation of kappa-opioid receptor with U50,488H, a selective kappa-opioid receptor agonist, produces any changes in electrical coupling during prolonged ischemia and whether these changes in electrical coupling is associated with the cardioprotection induced by U50,488H. It was found that U50,488H concentration dependently increased formazan content and reduced lactate dehydrogenase (LDH) release induced by 30 min of ischemia and 120 min of reperfusion, and the ameliorating effect of $10^{-5}$ mol/L U50,488H was abolished by $5times10^{-6}$ mol/L nor-binaltorphimine (nor-BNI), a selective kappa-opioid receptor antagonist, or $10^{-4}$ mol/L 5-hydroxydecanoate (5-HD), a selective mitochondrial ATP-sensitive $K^{+}$ $(K_{ATP})$ channels blocker. The onset of electrical uncoupling during prolonged ischemia was delayed by U50,488H, and delaying effect was not only abolished, but also advanced by nor-BNI or 5-HD compared with control group. These results demonstrate that delayed electrical uncoupling is associated with the cardioprotection induced by U50,488H. These effects of U50,488H are mediated by mitochondrial $K_{ATP}$ channels
Starting Page	126
Ending Page	129
File Size	219417
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616358
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Couplings Ischemic pain Cardiology Physiology Delay effects Rats Myocardium Heart rate Electric resistance Humans
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The Effects of Heptanol on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart

EFFECTS OF HUMAN SUPEROXIDE DISMUTASE ON ISCHEMIC AND REPERFUSED MYOCARDIUM IN ISOLATED PERFUSED RAT HEART

Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion

RESPONSE OF ISOLATED PERFUSED HEART TO ISCHEMIA AFTER LONG-TERM TREATMENT OF SPONTANEOUSLY HYPERTENSIVE RATS WITH DILTIAZEM : 51st Annual Meeting of the Japanese Circulation Society

Effects of Nicardipine on Ischemic Mechanical Failure and Tissue Injury in Isolated Perfused Rat Heart

FUNCTIONAL AND METABOLIC RESPONSES TO ISCHEMIA IN THE PERFUSED HEART ISOLATED FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

Effects of 7-Hydroxycoumarin (Umbelliferone) on Isolated Perfused and Ischemic-Reperfused Rat Heart

Parasympathetic muscarinic stimulation limits noradrenaline induced myocardial creatine kinase release: A study in the isolated perfused working rat heart

Protective effects of ischemic preconditioning on myocardial ischemia reperfusion injury

The Effects of κ-Opioid Receptor Stimulation on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart

Similar Documents

The Effects of Heptanol on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart

EFFECTS OF HUMAN SUPEROXIDE DISMUTASE ON ISCHEMIC AND REPERFUSED MYOCARDIUM IN ISOLATED PERFUSED RAT HEART

Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion

RESPONSE OF ISOLATED PERFUSED HEART TO ISCHEMIA AFTER LONG-TERM TREATMENT OF SPONTANEOUSLY HYPERTENSIVE RATS WITH DILTIAZEM : 51st Annual Meeting of the Japanese Circulation Society

Effects of Nicardipine on Ischemic Mechanical Failure and Tissue Injury in Isolated Perfused Rat Heart

FUNCTIONAL AND METABOLIC RESPONSES TO ISCHEMIA IN THE PERFUSED HEART ISOLATED FROM NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS

Effects of 7-Hydroxycoumarin (Umbelliferone) on Isolated Perfused and Ischemic-Reperfused Rat Heart

Parasympathetic muscarinic stimulation limits noradrenaline induced myocardial creatine kinase release: A study in the isolated perfused working rat heart

Protective effects of ischemic preconditioning on myocardial ischemia reperfusion injury

The Effects of &#954;-Opioid Receptor Stimulation on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart

The Effects of κ-Opioid Receptor Stimulation on Electrical Coupling during Ischemia in the Perfused Isolated Rat Heart