NDLI: The Relationship of Ventricular Dynamics and Mitochondrial Nitric Oxide Synthase Activity in Septic Shock Models

Content Provider	IEEE Xplore Digital Library
Author	Ce Xu Zhiguo Ye Qin Gao Qixian Shan Bourreau, J.-P. Qiang Xia
Copyright Year	2005
Description	Author affiliation: Dept. of Physiol., Zhejiang Univ. Sch. of Med., Hangzhou (Ce Xu; Zhiguo Ye; Qin Gao; Qixian Shan)
Abstract	The aim of the present study was to investigate the role of mitochondrial nitric oxide synthase (mtNOS) in the septic shock and analyze its relationship to ventricular contractility. Two models of septic shock [lipopolysaccharide (LPS)-induced and cecal ligation and puncture (CLP)-induced] were used. There was a significant depression of ventricular contractile parameters recorded in the late stage of the septic shock. After measurement of ventricular-dynamic parameters, mitochondrial and cytoplasmic fractions were isolated and their nitric oxide synthase (NOS) activity was assessed using a NOS activity assay kit. Both models showed a larger increase in mitochondrial NOS activity than that in cytosol. However, the increase in mtNOS activity in the LPS-induced shock model was less pronounced than in the CLP-induced model. Regression analysis shows that mitochondrial nitric oxide synthase (mtNOS) activity is negatively correlative to the left ventricular developed pressure in CLP model. The results suggest that mitochondrial NOS may mainly contribute to the ventricular depression in the septic shock
Starting Page	2280
Ending Page	2282
File Size	234533
Page Count	3
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616919
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric shock Rats Physiology Surgery Heart rate Regression analysis Humans Pathological processes Testing Chemicals
Content Type	Text
Resource Type	Article

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