NDLI: Evaluation of Alginate coated Chitosan Membrane for Guided Tissue Regeneration

Content Provider	IEEE Xplore Digital Library
Author	Shyh Ming Kuo Shwu Jen Chang Yun Ting Hsu Ta Wei Chen
Copyright Year	2005
Description	Author affiliation: Dept. of Biomed. Eng., I-Shou Univ., Kaohsiung (Shyh Ming Kuo; Shwu Jen Chang; Yun Ting Hsu)
Abstract	Chitosan membranes prepared by a thermal induced phase separation method and then alginate was coated onto the membrane on one side by a modified dialysis apparatus to prepare alginate/chitosan membranes (A/C membranes). ESCA analysis, SEM observation and contact angle measurements were conducted to evaluate the differences existed in the surface properties. Besides, mechanical strength, degradation behavior and especially, cell adhesion test was also examined to survey the feasibility of using this type of A/C membrane in guided tissue regeneration (GTR) application. The preliminary results obtained revealed that alginate could effectively be coated onto the chitosan membrane (from ESCA and SEM results). The contact angle decreased on the alginate side as compared with the chitosan-side (from 88.4deg to 34.2deg). The A/C membrane had a water higher content of 71.8 % as compare with the chitosan membrane (61.8%). Chitosan membranes coated with alginate also increased the Young's modulus and the ultimate strength, whereas, the elongation of these membranes were remained at the same range. A/C membrane and chitosan membrane prepared in this study degraded to about 75% of initial weight after a 30-day in vitro shaking test. The 3T3 fibroblast cells showed less adhesive on alginate side as compared with the chitosan side and glass surface in cell adhesion test. The obtained results from this study suggested that the alginate molecules could be coated onto the chitosan membrane by our modified dialysis apparatus and provided a different surface morphological structures and properties of chitosan membrane. This A/C membrane could provide extra benefits and potentials than chitosan membrane used in GTR applications
Starting Page	4878
Ending Page	4881
File Size	215282
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1615565
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biomembranes Adhesives Surface morphology Degradation Testing Regeneration engineering Goniometers Biological materials Coatings Biomedical engineering cell adhesion chitosan alginate guided tissue regeneration
Content Type	Text
Resource Type	Article

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