NDLI: Construction of Devices in Bioartificial Liver Support System

Content Provider	IEEE Xplore Digital Library
Author	Jianfeng Liu Ming Li Wei Yang Hanfen Lou
Copyright Year	2005
Description	Author affiliation: Inst. of Electr. Eng., Chinese Acad. of Sci., Beijing (Jianfeng Liu; Ming Li; Wei Yang; Hanfen Lou)
Abstract	An automatic control device in bioartificial liver support system is designed and implemented. Details of the hardware structure, design of the control system and the applied software in the device are described. Main controller uses the WS-843AW industrial control computer; precision electromagnetic valves are selected as implements to control the flux of three-gases (oxygen, carbon dioxide and nitrogen). The interconnected rule of controlled parameters in the system is analysed, and then matched by the mass balance equation. By a series of logic judgements of signals from sensors and direct digital calculations (DDC), a simple proportional plus integral (PI) controller can firstly manipulate the operations of electromagnetic valves, and then the on-line and off-line predictive control algorithm is used in accordance with practical experience to meet the requirements of the parameters in the culture and metabolism of hepatocytes. Software based on Visual C++ is implemented. All these serve to ensure high operational reliability, expansibility and better maneuverability of the whole system. Experiments show that this method can achieve sound performances in practice although there exist very strong coupling, dead-delay and lots of non-linear factors in the bioreactor. The controlling range is: dissolved oxygen 0-200plusmn5%; pH 6-8plusmn0.05pH; temperature 20-45plusmn0.1degC. The device can work in a steady state, and the control precision is high. It can meet the needs in the bioartificial liver support system, and hopefully improve clinical therapeutic effect
Starting Page	6699
Ending Page	6702
File Size	271139
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616040
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Liver Automatic control Control systems Valves Hardware Industrial control Carbon dioxide Nitrogen Weight control Integral equations predictive control Bioartificial liver support system bioreactor devices automatic controller dissolved oxygen temperature pH direct digital calculations hepatocytes culture interactive control
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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