NDLI: Time-varying analysis of autonomic control during arousal from sleep in obstructive sleep apnea syndrome

Content Provider	IEEE Xplore Digital Library
Author	Blasi, A. Jo, J. Valladares, E. Juarez, R. Baydur, A. Khoo, M.C.K.
Copyright Year	2003
Description	Author affiliation: Dept. of Biomed. Eng., Southern California Univ., Los Angeles, CA, USA (Blasi, A.; Jo, J.; Valladares, E.)
Abstract	Patients with obstructive sleep apnea syndrome (OSAS) have elevated sympathetic drive and impaired parasympathetic cardiac control during wakefulness and sleep. Previous studies have demonstrated that sympathetic overactivity in OSAS can lead to impaired peripheral vasodilatory responses to hypoxia. The present study was conducted to determine whether the autonomic response to arousal from sleep is also altered in OSAS. In 8 OSAS and 8 normal controls, we performed time-varying spectral analyses of cardiovascular and respiratory variability following acoustically-induced arousal from sleep. In all subjects and in both REM and non-REM sleep, the arousal responses of the spectral parameters representing vagal heart-rate modulation were small or non-existent after accounting for the accompanying changes in respiration. In non-REM sleep, the OSAS subjects showed substantially attenuated cardiac sympathetic responses to arousal but the peripheral vascular response was preserved. In REM sleep, the sympathetic cardiovascular responses to arousal were similar in both subject groups, but these responses were much smaller than those exhibited by normals in non-REM sleep. Our results suggest that OSAS leads primarily to an impairment of the cardiac sympathoexcitatory reaction to arousal from non-REM sleep; however, the normal autonomic cardiovascular response to arousal in REM sleep appears to be preserved.
Sponsorship	Whitaker Found
Starting Page	350
Ending Page	353
File Size	462488
Page Count	4
File Format	PDF
ISBN	0780377893
ISSN	1094687X
DOI	10.1109/IEMBS.2003.1279647
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-09-17
Publisher Place	Mexico
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sleep apnea Cardiology Spectral analysis Signal processing algorithms Biomedical engineering Control systems Autonomic nervous system Hypertension Cardiovascular diseases Heart rate variability
Content Type	Text
Resource Type	Article

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