NDLI: A Neuro-behavioral Test and Algorithms for Screening and Evaluating Therapy in ADHD

Content Provider	IEEE Xplore Digital Library
Author	Modarres-Zadeh, M. Xueyan Xu Jaromczyk, A. Senders, S.
Copyright Year	2005
Description	Author affiliation: CleveMed NeuroWave Inc., Cleveland, OH (Modarres-Zadeh, M.; Xueyan Xu; Jaromczyk, A.)
Abstract	A new neuro-behavioral test with analysis algorithms has been developed for use in screening individuals for attention deficit hyperactivity disorder (ADHD) and for the quantitative evaluation of ADHD medication/therapy in diagnosed patients. This technique combines a 15 minute auditory-based test of attention with simultaneous EEG monitoring by a wireless, portable data acquisition device. This system acquires both behavioral response (i.e., reaction times to target stimuli, as well as errors of omission/commission) and EEG waveforms. All of the data is simultaneously processed by the algorithms to produce several representative indices. These indices are then combined to produce an overall neurobehavioral index that represents the degree by which both "behavioral" and "EEG" attention is maintained throughout the test. This test was administered to 5 normal adolescents, and 5 aged-matched children with ADHD who were tested immediately before and one hour after their daily intake of ADHD medication. Both EEG-based and behavioral-response indices were statistically different in ADHD (before medication) compared with normal children. Furthermore, these indices showed an improvement after ADHD medication (values closer to those from normal children). Finally, the combined neuro-behavioral index was significantly more discriminating (normal vs pre-medication ADHD) and sensitive to medication than the indices solely based on EEG or behavioral response alone
Starting Page	2486
Ending Page	2489
File Size	191348
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616973
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Testing Medical treatment Medical diagnostic imaging Electroencephalography Medical tests Pediatrics Algorithm design and analysis Patient monitoring Data acquisition Time factors
Content Type	Text
Resource Type	Article

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