NDLI: Analyzing effects of sodium pentobarbital on hemodynamic responses by using a graphic control system

Content Provider	IEEE Xplore Digital Library
Author	Hung, C.-Y. Li, J.-Y. Kuo, T.-S. Jaw, F.-S.
Copyright Year	2005
Description	Author affiliation: Inst. of Biomed. Eng., National Taiwan Univ., Taipei (Hung, C.-Y.)
Abstract	The maintenance of adequate anesthesia is very important for animal studies. This goal could be achieved if the pharmacokinetics of the anesthetic is known and a well-controlled instrument system is used. To this end, a graphic control system is developed to study the effects of sodium pentobarbital on anesthesia. Hemodynamic signals such as mean blood pressure, pulse pressure, heart rate were analyzed and used as index for quantitative evaluating the level of anesthesia. Factors that could affect the anesthesia, e.g. body weight (BW) of the rat and the concentration of pentobarbital were used as independent variables to examine the survival time (dependent variable) for an overdosage anesthesia. The relationship among the BW, the drug concentration, and the survival time before death were formulated. As most physiological system have shown, the empirical relationship is exponential in nature. This implies that the mechanism is highly nonlinear and it is complicated by the buffering characteristics of life. Hence, a precision feedback control system seems to be necessary for a well-controlled anesthesia
Starting Page	59
Ending Page	61
File Size	256609
Page Count	3
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616341
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Hemodynamics Graphics Control systems Anesthesia Animals Anesthetic drugs Instruments Blood pressure Heart rate Signal analysis PC anesthesia automatic control blood pressure sodium pentobarbital
Content Type	Text
Resource Type	Article

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