NDLI: The Characterization and Imaging Behavior of a New Developed Paramagnetic Contrast Agent NMG2[Gd(TTDA-BOM)]

Content Provider	IEEE Xplore Digital Library
Author	Jo-Chi Jao Yun-Ming Wang Ming-Hung Ou Shih Hsie Chen Yen-Ku Chen Twei-Shiun Jaw Gin-Chung Liu Po-Chou Chen
Copyright Year	2005
Description	Author affiliation: Fac. of Radiol. Sci., Kaohsiung Medical Univ. (Jo-Chi Jao)
Abstract	$[Gd(TTDA-BOM)]^{2-}$ is a newly developed paramagnetic contrast agent. The ligand, TTDA-BOM, bears a benzyloxymethyl group so that the lipophilicity is increased. The water exchange rate for $[Gd(TTDA-BOM)]^{2-}$ is significantly higher than that of $[Gd(DTPA)]^{2-}$ and $[Gd(BOPTA)]^{2-}.$ In addition, the bound relaxivity of this Gd (III) complex has a remarkably high value with HSA. Therefore, it has potential to be used as a blood pool contrast agent for MRI. The aim of this study is to investigate the characterization and imaging behavior of $NMG_{2}[Gd(TTDA-BOM)]$ in normal rat livers and hearts using a 3T high field whole-body MR scanner. The high field MR scanner is expected to have a higher signal to noise ratio. The relaxivities $r_{1}$ and $r_{2}$ for $[Gd(TTDA-BOM)]^{2-}$ at 3T are 5.97 $mM^{-1}$ $s^{-1}$ and 7.99 $mM^{-1}$ $s^{-1}$ respectively, which are higher than those for $[Gd(DTPA)]^{2}$ $(r_{1}=4.64$ $mM^{-1}$ $s^{-1}$ and $r_{2}=5.08$ $mM^{-1}$ $s^{-1}).$ The dynamic MRI studies show that there is marked enhancement in livers and hearts right after the bolus injection and the enhancement ratios keep high until two hours. In conclusion, $[Gd(TTDA-BOM)]^{2-}$ might have a good potential in both cardiovascular and hepatobiliary applications
Starting Page	1650
Ending Page	1651
File Size	152568
Page Count	2
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616756
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Paramagnetic materials Biomedical imaging Magnetic resonance imaging Liver Heart Exchange rates Blood Signal to noise ratio Nuclear magnetic resonance Thickness measurement 3T Magnetic Resonance Imaging paramagnetic contrast agent Gd(TTDA-BOM) Gd(DTPA)
Content Type	Text
Resource Type	Article

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