NDLI: Chemical Sensing and Control in Cell & Tissue Bioreactors

Content Provider	IEEE Xplore Digital Library
Author	Rolfe, P.
Copyright Year	2005
Description	Author affiliation: Dept. of Commun., Genova Univ. (Rolfe, P.)
Abstract	To meet needs in cell and tissue engineering bioreactors are evolving to allow cells and tissues to be cultured under precisely defined physical and chemical conditions. Many cell-tissue types are now being cultured, and considered in this work are chondrocytes, vascular endothelial cells, and smooth muscle cells. The culture processes are dynamic and optimisation requires monitoring of key process variables. The chemical sensing in cell and tissue bioreactors described here has the long term aim of achieving automatic optimal control. Invasive and non-invasive electrochemical and optical systems are described for a wide range of target analytes (gases, ions, metabolites, hormones and proteins), but emphasis is on $O_{2},$ pH, $CO_{2}$ and glucose. The sensing is performed with: (a) interrogation via the bioreactor wall; (b) probes placed within the cell culture chamber; (c) analysis within a shunt/sampling chamber. Analysis of culture medium is used for measurement of glucose and for proteins that are markers of cell biosynthetic behaviour. Optical absorbance and scatter of cells and tissues are also investigated for both chemical and structural analysis
Starting Page	7486
Ending Page	7489
File Size	287222
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616243
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Bioreactors Cells (biology) Optical scattering Biomedical optical imaging Optical sensors Proteins Sugar Chemical analysis Tissue engineering Chemical engineering tissue engineering bioreactors cell and tissue culture optical sensors cellular engineering
Content Type	Text
Resource Type	Article

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Chemical Sensing and Control in Cell &amp; Tissue Bioreactors

Chemical Sensing and Control in Cell & Tissue Bioreactors