NDLI: Changes of aortae and pulmonary arteries under simulated microgravity and effects of NOS inhibitor on cardiovascular deconditioning

Content Provider	IEEE Xplore Digital Library
Author	De-sheng Wang Wen-bin Liang Ming Yuan Zhi-li Li Zhao-xia Liu Min Yuan Yao-yu Guo Tie-min Ma Jian-wen Dong
Copyright Year	2005
Description	Author affiliation: Inst. of Space Medico-Eng., Beijing (De-sheng Wang; Wen-bin Liang; Ming Yuan; Zhi-li Li; Zhao-xia Liu; Min Yuan; Yao-yu Guo)
Abstract	The present study was to determine the effects of simulated microgravity (SM) on the pulmonary artery (PA)and aorta(TA), and to disclose the changes in pathophysiology of cardiovascular deconditioning(CVD) induced by SM and to explore the effects of NOS inhibitor (N-nitro-L-arginine methylester, L-NAME) on CVD. The high hemodynamics in pulmonary and systemic circulation of human bodies appeared during the initial period and super-regulatory phenomena under 6deghead-down tilt bed rest. -30deg tail-suspension resulted in the functional changes, structural remodeling and the changes of ecNOS mRNA and iNOS mRNA in PA and TA endothelial cells from rats. $10^{-5}$ M L-NAME reversed the decrease of contractile response in PA and partly did in TA. The CVD in tail-suspension rats was relative to an increase of NO production from endothelial cells. $10^{-6}$ M L-NAME had an alleviating effect on CVD in tail-suspension rats. NOS inhibitor may have a good foreground in alleviating orthostatic intolerance
Starting Page	4509
Ending Page	4509
File Size	144338
Page Count	1
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1615470
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Arteries Inhibitors Cardiology Medical simulation Rats Biological system modeling Samarium Engineering in medicine and biology Hemodynamics Humans orthostatic tolerance artery endothelial cell NOS
Content Type	Text
Resource Type	Article

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