NDLI: Ultrasonic high frequency blood flow imaging of small animal tumor models

Content Provider	IEEE Xplore Digital Library
Author	Pai-Chi Li Yen-Fu Chen Wei-Jung Guan
Copyright Year	2003
Description	Author affiliation: Dept. of Electr. Eng., National Taiwan Univ., Taipei, Taiwan (Pai-Chi Li; Yen-Fu Chen; Wei-Jung Guan)
Abstract	In this paper, a 45 MHz ultrasonic small animal imaging systems and its applications in blood flow measurements on mouse tumors are presented. Specifically, the system was used to perform in vivo mouse imaging with a tumor cell line named WF-3. The WF-3 tumor cells were injected into the C57BL/6 mice subcutaneously and it was used as an ovarian cancer model. Vascularity of the tumor was successfully imaged when the diameter of the tumor was around 2 mm with flow velocities on the order of a few mm/s. The blood flow images were also correlated with histology after the mice were sacrificed. Good correlation between the blood flow images and the histology was demonstrated in that the lack of blood flow signals in the image for a tumor at a late development stage corresponded to necrosis at the center of the tumor shown in histology.
Starting Page	1598
Ending Page	1601
File Size	930964
Page Count	4
File Format	PDF
ISBN	0780379225
DOI	10.1109/ULTSYM.2003.1293214
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-10-05
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Frequency Blood flow Ultrasonic imaging Animals Neoplasms Mice Tumors Fluid flow measurement Ultrasonic variables measurement In vivo
Content Type	Text
Resource Type	Article

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