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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Xiangdong Xue Marson, S. Patel, M.K. Attia, U.M. Bailey, C. O'Neill, W. Topham, D. Desmulliez, M. |
| Copyright Year | 2010 |
| Description | Author affiliation: MISEC, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK (Desmulliez, M.) || School of Engineering and Design, Brunel University, Uxbridge, Middlesex, UB8 3PH, UK (Topham, D.) || Institute for Manufacturing, Department of Engineering, University of Cambridge, Cambridge CB2 1RX, UK (O'Neill, W.) || School of Computing and Mathematical Sciences, University of Greenwich, London SE10 9LS, UK (Xiangdong Xue; Patel, M.K.; Bailey, C.) || Department of Materials, Cranfield University, Cranfield, Bedford MK43 0AL, UK (Marson, S.; Attia, U.M.) |
| Abstract | This paper describes the design and development cycle of a 3D biochip separator and the modelling analysis of flow behaviour in the biochip microchannel features. The focus is on identifying the difference between 2D and 3D implementations as well as developing basic forms of 3D microfluidic separators. Five variants, based around the device are proposed and analysed. These include three variations of the branch channels (circular, rectangular, disc) and two variations of the main channel (solid and concentric). Ignoring the initial transient behaviour and assuming steady state flow has been established, the efficiencies of the flow between the main and side channels for the different designs are analysed and compared with regard to relevant bio-microfluidic laws or effects (bifurcation law, Fahraeus effect, cell-free phenomenon, bending channel effect and laminar flow behaviour). The modelling results identify flow features in microchannels, a constriction and bifurcations and show detailed differences in flow fields between the various designs. The manufacturing process using injection moulding for the initial base case design is also presented and discussed. The work reported here is supported as part of the UK funded 3D-MINTEGRATION project. |
| Starting Page | 1021 |
| Ending Page | 1030 |
| File Size | 1326114 |
| Page Count | 10 |
| File Format | |
| ISBN | 9781424464104 |
| ISSN | 05695503 |
| e-ISBN | 9781424464128 |
| e-ISBN | 9781424464111 |
| DOI | 10.1109/ECTC.2010.5490827 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-06-01 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Microchannel Numerical analysis Particle separators Bifurcation Microfluidics Solids Transient analysis Steady-state Manufacturing processes Injection molding |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering |
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