NDLI: Scatter Correction Requirements for Likelihood-Based Attenuation Artifact Correction in PET

Content Provider	IEEE Xplore Digital Library
Author	Laymon, C.M. Bowsher, J.E. Carney, J.P.J. Blodgett, T.M.
Copyright Year	2006
Description	Author affiliation: Pittsburgh Univ., PA (Laymon, C.M.; Bowsher, J.E.; Carney, J.P.J.)
Abstract	Artifacts have been observed in CT-based, 511-keV attenuation images for PET attenuation correction. Artifact detection and correction algorithms are being developed based on the Poisson log likelihood function (LLF). The LLF quantifies the level of consistency between an activity and attenuation image pair and the measured emission sinogram. We have shown that the LLF can discriminate more-artifactual from less-artifactual attenuation images at clinical noise levels. Here we use a digital anthropomorphic phantom to examine the effect of scatter on LLF performance. Base sinograms were formed by forward projecting a true activity distribution through a true attenuation distribution. Scatter was simulated by filtering the base sinograms. Noise was considered by producing 128 Poisson-randomized variates of the filtered base sinograms for each of 7 assumed count levels. An artifactual attenuation image was produced by modifying mu-values of regions of the true attenuation image. For each sinogram, two OSEM reconstructions were performed and two LLF values obtained using the artifactual and true attenuation. Accuracy was calculated as the fraction of cases in which the LLF preferred the artifact-free attenuation image. Additional studies were performed to test several scatter correction procedures. Findings show that scatter may render the LLF unreliable even in the limit of high-count scans but that its usefulness is restored by applying an appropriate correction.
Starting Page	2151
Ending Page	2154
File Size	108529
Page Count	4
File Format	PDF
ISBN	1424405602
ISSN	10957863
DOI	10.1109/NSSMIC.2006.354340
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-29
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Scattering Positron emission tomography Noise level Attenuation measurement Anthropomorphism Imaging phantoms Filtering Image reconstruction Accuracy Performance evaluation Xray tomography
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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