NDLI: Experimental study on irreversible electrical breakdown of tumor cell under steep pulsed electric fields

Content Provider	IEEE Xplore Digital Library
Author	Sun Caixin Yao Chenguo Mi Yan Xiong Lan Liao Ruijin Hu Lina Hu Ya
Copyright Year	2002
Description	Author affiliation: Key Lab of High Voltage Eng. & Electr. New Technol., Minist. of Educ., Chongqing, China (Sun Caixin; Yao Chenguo; Mi Yan; Xiong Lan; Liao Ruijin)
Abstract	Describes the dynamic changes of the SKOV3 cancer cell under steep pulsed electric fields (SPEFs, generated by the energy-controllable steep pulse apparatus for tumor treatment) using an inverted phase contrast microscope (IPCM) and finds that the cell was swollen in very short time. The study showed that the membrane of treated cell was destroyed under a scanning electron microscope (SEM), the nucleus was swollen and its karyotheca was not integrated under the transmission electron microscope (TEM). The mitochondria was also cavitated and swollen. It is clear that the SPEFs can result in irreversible electrical breakdown of the tumor cell. It may be a new therapy for tumor treatment.
Starting Page	1675
Ending Page	1676
File Size	207212
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106597
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric breakdown Tumors Cancer Biomembranes Cells (biology) Medical treatment Neoplasms Drugs Scanning electron microscopy Voltage
Content Type	Text
Resource Type	Article

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