NDLI: Reentry formation during ventricular fibrillation

Content Provider	IEEE Xplore Digital Library
Author	Gray, R.A. Banville, I.
Copyright Year	2002
Description	Author affiliation: Dept. of Biomed. Eng., Alabama Univ., Birmingham, AL, USA (Gray, R.A.; Banville, I.)
Abstract	Sudden cardiac death caused by ventricular fibrillation (VF) is the leading cause of death in the industrialized world. It is thought that multiple unstable reentrant spiral waves are the underlying cause of VF. According to the "restitution hypothesis", reentrant waves form due to a cellular instability resulting in alternans leading to conduction block. Alternans are thought to occur when the slope of the restitution curve (i.e., the relationship of APD to its preceding diastolic interval DI) is >1. A video imaging system capable of recording transmembrane potential with high temporal and spatial resolution was used to study the mechanisms of reentry formation during VF in isolated pig hearts. Restitution curves were constructed during steady state pacing at progressively shorter pacing intervals. The slope of the restitution curves was >1 for DIs<82 msec. During VF, reentrant waves frequently formed in regions where impulse propagation was impaired in previous beats. First, impulse propagation slowed, conduction block occurred but no reentry was initiated. Second, the impulse propagated in the retrograde direction forming reentry in the region where black had occurred. These events were not associated with APD alternans despite the fact that during VF DI values were always less than 82 ms.
Starting Page	1356
Ending Page	1357
File Size	191262
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106426
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fibrillation Heart Fluorescence Biomedical engineering Industrial accidents Spirals High-resolution imaging Video recording Spatial resolution Steady-state
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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