NDLI: Inflammation depresses electrical conduction in normal heart tissue

Content Provider	IEEE Xplore Digital Library
Author	Tselentakis, E.V. Gaudette, G.R. Saltman, A.E.
Copyright Year	2002
Description	Author affiliation: Dept. of Biomed. Eng., State Univ. of New York, Stony Brook, NY, USA (Tselentakis, E.V.; Gaudette, G.R.; Saltman, A.E.)
Abstract	Up to 40% of patients that undergo cardiac surgery will experience atrial fibrillation. Because it has been shown that there is an inflammatory response after open-heart surgery associated with elevated levels of arachidonic acid (AA), we postulated that inflammation leads to abnormal conduction and atrial fibrillation. We studied AA effects on conduction properties of canine atrial tissue. A piece of the right atrial free wall was placed in a tissue bath and a bipolar recording electrode was placed a known distance from a point stimulator. Control recordings revealed two groups, one with high conduction velocity (CV) (63.39/spl plusmn/3.06 cm/sec) and one with low CV (36.48/spl plusmn/0.34 cm/sec, p<0.05 vs. high CV). AA (80 /spl mu/M) was superfused for 15 minutes, and then washed out. AA caused a significant and reversible decrease of 44% in the slow CV group (n=3) whereas in the other group (n=3), there was little observed change (12%). The group with slower baseline CV responded to AA, whereas the group with higher CV was unaffected by AA. We postulate that the group with higher CV demonstrated conduction properties along the fiber long axis, whereas the group with slower velocities indicated conduction transverse to the long axis.
Starting Page	1449
Ending Page	1450
File Size	145563
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106476
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Heart Atrial fibrillation Surgery Enterprise resource planning Electrodes Biomedical engineering Cardiology Hospitals Temperature control Silver
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in