NDLI: Biventricular defibrillation with sequential shocks using patient-derived computational models

Content Provider	IEEE Xplore Digital Library
Author	Mocanu ,. D. Kettenbach, J. Sweeney, M.O. Kikinis, R. KenKnight, B.H. Eisenberg, S.R.
Copyright Year	2002
Description	Author affiliation: Dept. of Biomed. Eng., Boston Univ., MA, USA (Mocanu , D.)
Abstract	Standard transvenous defibrillation is performed with implantable cardioverter defibrillators (ICD) using a dual-current pathway. The defibrillation energy is delivered from the right ventricle (RV) electrode to the superior vena cava (SVC) electrode and the ICD metallic housing. Clinical studies of biventricular defibrillation, which uses an additional electrode, placed on the left ventricular (LV) free wall, in conjunction with sequential shocks, have reported a 50% reduction in defibrillation threshold (DFT) energy. The goal of our study is to use computational methods to examine the biventricular defibrillation fields together with their corresponding DFTs, and to compare to standard defibrillation. Thoracic models derived from 5 patients were used in this study. The computational models were created from segmented CT images. The electric field distribution during defibrillation was computed using the finite volume method. The critical mass hypothesis was used to define a successful shock and to calculate the DFT. Our simulations show that the biventricular lead system reduces the DFT by 30% in comparison to standard configuration in 3 of the models and increases DFT up to 12% in the remaining 2. These results are consistent with clinical reports and suggest that patient-specific computational models may be able to identify those patients who could benefit from biventricular defibrillation.
Starting Page	1441
Ending Page	1442
File Size	186587
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106472
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Defibrillation Electric shock Computational modeling Electrodes Cardiology Static VAr compensators Image segmentation Computed tomography Distributed computing Finite volume methods
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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