NDLI: Effect of shock timing on cardioversion efficacy

Content Provider	IEEE Xplore Digital Library
Author	Evans, F.G. Ideker, R.E. Gray, R.A.
Copyright Year	2002
Description	Author affiliation: Dept. of Biomed. Eng., Alabama Univ., Birmingham, AL, USA (Evans, F.G.; Ideker, R.E.; Gray, R.A.)
Abstract	Attempts to improve defibrillation efficacy by timing the shock to local or global measures of electrical activity during ventricular fibrillation have been inconclusive, and the proposed mechanisms for such a benefit remain speculative. Using video imaging technology, we recorded transmembrane potential (Vm) from /spl sim/5000 sites over the anterior and posterior ventricular epicardium of 6 Langendorff-perfused rabbit hearts during cardioversion of stable reentrant arrhythmias. Monophasic shocks at three strengths (0.75, 1.5, and 3.0 A) for each polarity were delivered between electrodes inside the right ventricle (RV) and above the left atrium multiple times. Cardioversion efficacy at the three strengths was 21%, 42%, and. 92% for RV+ shocks, which primarily depolarized the epicardium, and 10%, 15%, and 33% for RV- shocks, which primarily hyperpolarized the epicardium. Outcome was dependent on the pre-shock state for both polarities at strengths near the 50% success level. Preceding successful shocks, more epicardium was recovered resulting in more shock-induced excitation and longer post-shock depolarization (for RV+) and faster post-shock elimination of excitable gaps (for RV-) compared to failures. These findings provide a mechanistic link between shock-induced changes in Vm and the effect of polarity and timing on cardioversion efficacy.
Starting Page	1426
Ending Page	1427
File Size	171452
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106463
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric shock Timing Cardiology Virtual manufacturing Defibrillation Electric variables measurement Fibrillation Rabbits Heart Electrodes
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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