NDLI: Effect of nitric oxide synthase inhibition on arteriovenular control of capillary perfusion

Content Provider	IEEE Xplore Digital Library
Author	Nellore, K. Harris, N.R.
Copyright Year	2002
Description	Author affiliation: Dept. of Bioeng., Pennsylvania State Univ., University Park, PA, USA (Nellore, K.; Harris, N.R.)
Abstract	Postcapillary venules contribute to the control of arteriolar tone and therefore capillary perfusion. In a previous study of the rat mesentery, we found a significant correlation between capillary red blood cell velocity (V/sub RBC/) and the percent of the feeding arteriole length that was paired (proximity < 15 microns) with a postcapillary venule (% pairing). In the present study using the same model, we test whether nitric oxide (NO) is involved in the arteriovenular control of capillary perfusion. The baseline relationship between V/sub RBC/ and % pairing (p<0.001; positive slope of 0.079 mm/sec/%) not only is eliminated following NO synthase inhibition with L-NAME, but also becomes negative (p=0.004; -0.035 mm/sec/%). The negative correlation may indicate that in the absence of NO, venules (or venular leukocytes) promote constriction of nearby arterioles, therefore limiting capillary perfusion. For individual capillaries, the decrease in VRBC (L-NAME minus baseline) was highly correlated with % pairing (p<0.001; r/sup 2/=0.81), with the intercept near zero. This suggests that L-NAME has no effect on capillary perfusion when the arteriolar pathway lacks nearby venules, and that L-NAME has a maximal effect when arteriovenular pairing is high. These results confirm a role for NO in the control of capillary perfusion by arteriovenular communication.
Starting Page	1293
Ending Page	1294
File Size	152543
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106394
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Communication system control Rats Testing Intestines Red blood cells White blood cells Feeds Feedback control Muscles Animals
Content Type	Text
Resource Type	Article

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