NDLI: Lack of reperfusion-induced venular leukocyte adherence following local arteriolar ischemia

Content Provider	IEEE Xplore Digital Library
Author	Kulkami, N.P. Harris, N.R.
Copyright Year	2002
Description	Author affiliation: Dept. of Bioeng., Pennsylvania State Univ., University Park, PA, USA (Kulkami, N.P.; Harris, N.R.)
Abstract	Leukocyte adhesion in postcapillary venules has been implicated as a primary determinant of microvascular dysfunction that occurs following ischemia-reperfusion (I/R). The mechanisms of leukocyte recruitment have not been fully established. The present study concerns evidence in the literature that I/R in one organ may initiate a systemic effect that results in inflammatory consequences in another. In this investigation, we used a model of mesenteric I/R in the rat. In one group (N = 13), I/R has induced by temporarily occluding the superior mesenteric artery (SMA) for 30 minutes. In the another group (N = 9), localized I/R was induced by micropipette occlusion of a mesenteric arteriole (for 30 minutes) that perfused the monitored venule(s). The responses of the two groups were different. No increase in venular leukocyte adherence was observed with local I/R; instead, there was a trend for a small decrease. In contrast, a significant increase in adherence (p<0.001) was observed with SMA I/R. Also of interest, both local and SMA I/R similarly prevented the decrease in leukocyte rolling that occurs in time control experiments following mesenteric exteriorization (N = 8). These results suggest that mesenteric I/R-induced leukocyte adherence (but not rolling) may be dependent on a mediator released into the systemic circulation.
Starting Page	911
Ending Page	912
File Size	158388
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106201
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	White blood cells Ischemic pain Injuries Intestines Adhesives Recruitment Arteries Rats Microscopy Biomedical engineering
Content Type	Text
Resource Type	Article

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