NDLI: Uncertainty analysis of measurement error in calculating vascular input impedance: how many harmonics can be resolved?

Content Provider	IEEE Xplore Digital Library
Author	Koenig, S.C. Schroeder, M.J. Wheeler, B. Jorgenson, J. Ewert, D.L.
Copyright Year	2002
Description	Author affiliation: Jewish Hosp. Cardiothoracic Surg. Res. Inst., Louisville Univ., KY, USA (Koenig, S.C.; Schroeder, M.J.)
Abstract	Vascular input impedance represents the hydraulic load seen by the ejecting ventricle and is represented by magnitude and phase components in the frequency domain derived from Fast Fourier Transform (FFT) of instantaneous vascular pressure and flow measurements. The resulting spectra consists of a mean or DC component and magnitude and phase information at harmonics of the fundamental frequency. The objective of this study was to determine how many harmonics could be faithfully reproduced as a function of measurement error associated with the instantaneous pressure and flow recordings using uncertainty analysis. Input impedance and uncertainty analysis algorithms were developed in Matlab. Simulated vascular pressure and flow waveforms were constructed by summing a series of sine waves of varying amplitude and phase to verify accuracy of the impedance and uncertainty m-files. Random normally distributed noise was injected into the simulated waveforms and a Monte Carlo analysis performed to verify the injected 'noise' which fell within the bounded limits. Using aortic pressure and flow data obtained experimentally in an acute animal model, the uncertainty error associated with pressure, flow, and sampling time errors for up to ten harmonics was determined. These results indicate that given high-fidelity data, the DC and up to six harmonics can be faithfully resolved.
Starting Page	1319
Ending Page	1320
File Size	158795
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106407
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Error analysis Harmonic analysis Measurement errors Frequency domain analysis Fast Fourier transforms Impedance measurement Frequency measurement Fluid flow measurement Phase measurement Pressure measurement
Content Type	Text
Resource Type	Article

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