NDLI: A closed-loop model of human gas exchange

Content Provider	IEEE Xplore Digital Library
Author	Lu, K. Clark, J.W. Ghorbel, F.H. Ware, D.L. Bidani, A.
Copyright Year	2002
Description	Author affiliation: Dynamical Syst. Group, Rice Univ., Houston, TX, USA (Lu, K.; Clark, J.W.; Ghorbel, F.H.)
Abstract	We have developed a closed-loop gas exchange model of the human. In our previous model of the human cardiopulmonary system, only gas transport at lungs were included, and the inlet blood O/sub 2/ and CO/sub 2/ concentrations to the lungs were fixed at constant values. We now add a description of the tissue gas exchanger, and couple these gas exchangers via the circulatory loop in our human cardiopulmonary model. Thus, gas transport in the lungs and at the blood-tissue interface interact as part of a closed-loop system, where the output of one gas exchanger provides the input to the other. The model predicts physiological variables that agree well with typically observed data in human, and also the simulated response to induced asphyxia. The study suggests an important role for transport delay in maintaining the arterial O/sub 2/ tension and resisting hypercapnia during asphyxia. The simulation results also show the existence of diffusion limitation of O/sub 2/ in tissue.
Starting Page	1535
Ending Page	1536
File Size	173945
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106523
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Humans Lungs Cardiology Blood Delay Filtration Predictive models Asphyxia Mathematical model Transportation
Content Type	Text
Resource Type	Article

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