NDLI: Lethal and inhibitory effects of steep pulsed electric field on tumor-bearing BALB/c mice

Content Provider	IEEE Xplore Digital Library
Author	Yan Mi Caixin Sun Chenguo Yao Lan Xiong Ruijin Liao Ya Hu Lina Hu
Copyright Year	2004
Description	Author affiliation: Chongqing Univ., China (Yan Mi; Caixin Sun; Chenguo Yao; Lan Xiong; Ruijin Liao)
Abstract	Exposing cancer cell to steep pulsed electric field (SPEF) with appropriate dosage, the cell may die due to irreversible electrical breakdown (IREB). 48 BALB/c mice inoculated with U/sub 14/ cervical cancer cell were treated with SPEF to study the lethal and inhibitory effects of SPEF on them. They were randomly divided into test group (26) and control group (22), and then four experiments were carried out. Histological observation and ultrastructural observation showed that SPEF destroyed the integrality of tumor cell irreversibly with pyknosis, karyoclasis and karyolysis. Tumor volume measurement indicated that SPEF significantly slowed down the growth speed of tumor. In the experiment of survival time investigation, the average survival time of control group and test group was 33.03 days and no less than 52.05 days respectively, which confirmed that SPEF prolonged the survival time of tumor-bearing mice obviously. With further experimental study and mechanism analysis, this technique is quite possible to be an effective physiotherapy for tumor treatment.
Starting Page	5005
Ending Page	5008
File Size	627386
Page Count	4
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404383
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mice Neoplasms Drugs Electric breakdown Cells (biology) Biomembranes Cervical cancer Testing Tumors Pulse generation steep pulsed electric field (SPEF) BALB/c mice cancer cell irreversible electrical breakdown (IREB) lethal and inhibitory effects
Content Type	Text
Resource Type	Article

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