NDLI: Alterations in collagen fiber crimp morphology with accelerated cyclic loading and transvalvular pressure fixation in porcine aortic valves

Content Provider	IEEE Xplore Digital Library
Author	Fulchiero, G.J. Wells, S.M. Sacks, M.S.
Copyright Year	2002
Description	Author affiliation: Tissue Mech. Lab., Pittsburgh Univ., PA, USA (Fulchiero, G.J.; Wells, S.M.; Sacks, M.S.)
Abstract	It is known that changes in the collagen fiber orientation of porcine bioprosthetic heart valves (PBHV) occur with (i) cyclic loading and (ii) fixation pressure. These changes correlate to alterations in biaxial extensibility, as reported by Wells et al. (2002). It is hypothesized that the increased collagen fiber alignment detected by small angle light scattering in (i) and (ii) is either due to the gross fiber splay, or a decrease in the colllagen fiber crimp (i.e. increase in crimp period). To address this hypothesis, we examined the changes in collagen fiber crimp morphology of PBHVs fixed at 0, 1, 2, and 4 mmHg transvalvular pressure, as well as 0 and 4 mmHg fixed PBHV following 0, 1/spl times/10/sup 6/, 50/spl times/10/sup 6/, 200/spl times/10/sup 6/, and 500/spl times/10/sup 6/ in vitro accelerated test cycles. Fast Fourier transform analysis of polarized light micrographs was used to calculate the collagen fiber crimp period. As PBHVs were fixed at increasing pressures, it was found that the crimp period increases from 15.2 /spl mu/m at 0 mmHg to 21.4 /spl mu/m at 4 mmHg. Additionally, a 65% increase in crimp period was observed between 0-50/spl times/10/sup 6/ cycles in the 0 mmHg fixed valves, while only an 18% increase in the 4 mmHg fixed valves over the same cycle duration. We conclude that decreasing collagen crimp is a primary mechanism contributing to PBHV cyclic fatigue damage.
Starting Page	1248
Ending Page	1249
File Size	175462
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106371
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Morphology Acceleration Optical fiber polarization Heart valves Light scattering In vitro Life estimation Fast Fourier transforms Optical fiber testing Fatigue
Content Type	Text
Resource Type	Article

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