NDLI: Residual strain changes with left ventricular pressure in the developing heart

Content Provider	IEEE Xplore Digital Library
Author	Wong, C.L. Miller, C.E.
Copyright Year	2002
Description	Author affiliation: Div. of Pediatric Cardiology, Rochester Univ., NY, USA (Wong, C.L.; Miller, C.E.)
Abstract	Residual stress and strain can result from mechanically induced growth and may help to optimize a tissue's load-bearing ability. We hypothesized that left ventricular (LV) residual strain changes after chronic pressure overload or underload in the stage 29 (6-d) embryonic chick. Stage 21 (3.5-d) chicks were treated with either conotruncal banding or extraembryonic verapamil drip until stage 29. LV pressure was measured in ovo. A transverse basal section through both ventricles was removed and a radial cut made in the LV wall to give zero-stress configuration. Opening angle, a measure of circumferential residual strain, was measured at interior, mid-wall, and exterior positions. Peak systolic pressures in control, banded, and verapamil-treated hearts were 4.73/spl plusmn/0.58, 7.32/spl plusmn/0.88 (p<0.001 vs control), and 3.70/spl plusmn/0.30 mmHg (p<0.001). Maximum and minimum dP/dt also changed significantly after both interventions. End diastolic pressures were similar in all. Heart rates were similar in control and banded but lowered after verapamil treatment. Opening angles were 42.0/spl deg//spl plusmn/9.7/spl deg/, 69.3/spl deg//spl plusmn/12.2/spl deg/ (p<0.001), and 31.3/spl deg//spl plusmn/8.1/spl deg/ (p<0.01). These increases and decreases in residual strain with increases and decreases in LV pressure may help normalize myocardial stress and strain.
Starting Page	1262
Ending Page	1263
File Size	165504
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106378
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Capacitive sensors Strain measurement Residual stresses Position measurement Pressure control Embryo Pressure measurement Goniometers Heart rate Myocardium
Content Type	Text
Resource Type	Article

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