NDLI: The influence of vacular function on left ventricular contraction/relaxation coupling

Content Provider	IEEE Xplore Digital Library
Author	Karamanoglu, M. Kovacs, S.J.
Copyright Year	2002
Description	Author affiliation: Cardiovascular Biophys. Lab., Washington Univ. Sch. of Med., St. Louis, MO, USA (Karamanoglu, M.; Kovacs, S.J.)
Abstract	Indexes of ventricular function have conventionally been classified into indexes of systolic (contractile) or diastolic (relaxation/stiffness) function. Systolic indexes include maximum elastance (Emax) or equivalently the end-systolic pressure volume relation (ESPVR) and left ventricular ejection fraction (LVEF). Diastolic indexes include the time constant of isovolumic relaxation (/spl tau/) and the end-diastolic pressure-volume relation (EDPVR). The conceptualization of ventricular contraction/relaxation coupling presents a challenge when mechanical events of the cardiac cycle are depicted in conventional pressure (P) or volume (V) terms. Additional conceptual difficulty arises when ventricular/vascular coupling is considered using P, V variables. In this preliminary work, we introduce the concept of thermodynamic phase-plane (TPP) defined by the PdV and VdP axes. TPP allows all cardiac mechanical events and their coupling to the vasculature to be geometrically depicted and simultaneously analyzed. Conventional systolic and diastolic function indexes are easily recovered, novel indexes of contraction-relaxation coupling are discernible and the influence of vascular function can be assessed.
Starting Page	1215
Ending Page	1217
File Size	167686
Page Count	3
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106355
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Thermodynamics Cardiology Cyclic redundancy check Biophysics Laboratories Animal structures Timing Energy consumption Potential energy Extracellular
Content Type	Text
Resource Type	Article

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