NDLI: Virtual electrode-induced phase singularity in a rabbit model of chronic myocardial infarction

Content Provider	IEEE Xplore Digital Library
Author	Cheng, Y. Zhuang, S. Nikolski, V. Efimov, I.R. Wallick, D.W.
Copyright Year	2002
Description	Author affiliation: Dept. of Cardiovascular Medicine, Cleveland Clinic Found., OH, USA (Cheng, Y.; Zhuang, S.)
Abstract	Shock-induced vulnerability and defibrillation have been mostly studied in a structurally normal heart, rarely the case in clinical settings. Increased vulnerability has been reported during ischemia, which is likely to contribute to defibrillation failure. The purpose of this study is to examine the mechanism of increased vulnerability after myocardial infarction (MI). Ligation of the marginal branch of the left circumflex artery in rabbits was done 1-6 weeks before acute experiments. Epicardial electrical activity of Langendorff-perfused hearts (n=4) was optically mapped before, during and after 8-ms monophasic shocks (150 microF) applied during T-wave from a right ventricular lead. Histology revealed that ligation consistently resulted in a discrete left ventricular apical infarction with a border zone (BZ) characterized by action potential shortening. Cathodal shocks produced the virtual electrode polarization pattern with an area of positive polarization near the shock lead and an adjacent area of negative polarization (de-excitation area). Maximum transmembrane voltage gradient was located in the BZ. The resulting postshock break-excitation wavefronts consistently originated at this gradient and propagated toward the base, forming a sustained reentrant arrhythmia. It was concluded that regional MI provides the substrate for increased vulnerability via virtual electrode-induced phase singularity, which originates in the BZ. This may contribute to defibrillation failure.
Starting Page	1430
Ending Page	1431
File Size	275738
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106465
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Rabbits Myocardium Defibrillation Electric shock Heart Ischemic pain Arteries Electrodes Optical polarization Voltage
Content Type	Text
Resource Type	Article

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