NDLI: Experimental studies on Killing and inhibiting effects of steep pulsed electric field (SPEF) to target cancer cell and solid tumor

Content Provider	IEEE Xplore Digital Library
Author	Chenguo Yao Caixin Sun Yan Mi Lan Xiong Shibin Wang
Copyright Year	1973
Abstract	Electroporation (i.e., reversible electrical breakdown) has been used for biomedicine such as electroporation therapy, transdermal drug delivery, cellular drug carrier systems, and gene transfer therapy. However, little research on the biological effect of irreversible electrical breakdown has been published. In this paper, the killing and inhibiting effects of pulsed electric field, whose rising edge is 100 ns level (we call it steep pulsed electric field, SPEF), to target cancer cell and solid tumor were successfully observed. The SPEF consists of two parts: the rising process containing ample high-frequency components, and the falling process containing lots of low-frequency components. Cell exposed to the pulse presented multiple changes: destructed membrane, swollen nucleus, disintegrated karyotheca, and cavitated, swollen mitochondria in histological and ultrastructure observations. SPEF blocked cell transition from G0/G1 phase to S+G2/M phase in flow cytometry analysis, and tumor growth retardation was observed in tumor-bearing mice. These experimental results show SPEF have a certain function to generate irreversible electrical breakdown in tumor cells, and might provide a new promising therapeutic approach for tumor treatment.
Sponsorship	IEEE Nuclear and Plasma Sciences Society
Starting Page	1626
Ending Page	1633
Page Count	8
File Size	2674882
File Format	PDF
ISSN	00933813
Volume Number	32
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-08-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Cancer Solids Neoplasms Drugs Biomembranes Cells (biology) Electric breakdown Medical treatment Mice Tumors
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Condensed Matter Physics

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