NDLI: Development of the MC3 BioLung/spl trade/

Content Provider	IEEE Xplore Digital Library
Author	Chambers, S.D. Merz, S.I. McGillicuddy, J.W. Bartlett, R.H.
Copyright Year	2002
Description	Author affiliation: MC3 Inc., Ann Arbor, MI, USA (Chambers, S.D.; Merz, S.I.)
Abstract	MC3 has previously developed a total artificial lung that can supply full pulmonary support, while imparting the appropriate impedance characteristics to allow perfusion by the right ventricle. To date, the MC3 device has been tested in healthy and sick animals, demonstrating both performance and improved survival. This article describes the engineering design and preliminary testing of the next generation of the MC3 device, called the BioLung/spl trade/. The design goals were to decrease the overall device size and remove areas of blood flow stasis in the fiber bundle to improve gas exchange efficiency and minimize thrombus formation. Based on CFD analysis and bench-top pressure-flow and gas exchange performance, we successfully decreased the fiber surface area 24%, while maintaining the oxygen transfer rates, and lowered the pressure drop by 10% to 40%. Animal studies without anticoagulation demonstrated that the new design removed the formation of thrombosis in the collection gap region between the fiber bundle and device housing, and decreased the amount of micro thrombi visible in the fiber bundle. Although these results are preliminary, they strongly suggest that the BioLung/spl trade/ design will be a significant step towards moving the MC3 artificial lung technology to clinical application.
Starting Page	1581
Ending Page	1582
File Size	172145
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106548
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical fiber devices Animals Lungs Testing Computational fluid dynamics Impedance Blood flow Anesthesia Arteries Valves
Content Type	Text
Resource Type	Article

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