NDLI: The influence of stretch-activated channels on defibrillation

Content Provider	IEEE Xplore Digital Library
Author	Weihui Li Eason, L.C. Kohl, P. Trayanova, T.A.
Copyright Year	2002
Description	Author affiliation: Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA (Weihui Li)
Abstract	Passive filling of the ventricles during fibrillation could engage stretch-activated ionic channels, which, in their turn, may alter the dynamics of fibrillation or defibrillation. We quantify the electrophysiological changes in myocardial tissue associated with the recruitment of stretch-activated channels and assess their effects on termination of a reentrant wavefront in a computational model. Our analysis reveals that stretch-activated channels elevate the resting potential, shorten the refractory period, increase propagation velocity, and alter the efficacy of shocks in terminating an arrhythmia. Most importantly, the involvement of stretch-activated channels causes the defibrillation dose-response curve to flatten; weak shocks are slightly more likely to succeed while strong shocks are more likely to fail.
Starting Page	1434
Ending Page	1435
File Size	129415
Page Count	2
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106467
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Defibrillation Myocardium Fibrillation Biomembranes Electric shock Multilevel systems Computational modeling Blood Geometry Spirals
Content Type	Text
Resource Type	Article

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