NDLI: SQUID-detected in vivo MRI at microtesla magnetic fields

Content Provider	IEEE Xplore Digital Library
Author	Mossle, M. Myers, W.R. Seung-Kyun Lee Kelso, N. Hatridge, M. Pines, A. Clarke, J.
Copyright Year	2002
Abstract	We use a low transition temperature (T/sub c/) Super-conducting Quantum Interference Device (SQUID) to perform in vivo magnetic resonance imaging (MRI) at magnetic fields around 100 microtesla, corresponding to proton Larmor frequencies of about 5 kHz. In such low fields, broadening of the nuclear magnetic resonance lines due to inhomogeneous magnetic fields and susceptibility variations of the sample are minimized, enabling us to obtain high quality images. To reduce environmental noise the signal is detected by a second-order gradiometer, coupled to the SQUID, and the experiment is surrounded by a 3-mm thick Al shield. To increase the signal-to-noise ratio (SNR), we prepolarize the samples in a field up to 100 mT. Three-dimensional images are acquired in less than 6 minutes with a standard spin-echo phase-encoding sequence. Using encoding gradients of /spl sim/100 /spl mu/T/m we obtain three-dimensional images of bell peppers with a resolution of 2/spl times/2/spl times/8 mm/sup 3/. Our system is ideally suited to acquiring images of small, peripheral parts of the human body such as hands and arms. In vivo images of an arm, acquired at 132 /spl mu/T, show 24-mm sections of the forearm with a resolution of 3/spl times/3 mm/sup 2/ and a SNR of 10. We discuss possible applications of MRI at these low magnetic fields.
Sponsorship	Council on Superconductivity Appl. Superconductivity Conference Inc MIT
Starting Page	757
Ending Page	760
Page Count	4
File Size	460643
File Format	PDF
ISSN	10518223
Volume Number	15
Issue Number	2
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vivo Magnetic resonance imaging Magnetic fields SQUIDs Signal to noise ratio Image resolution Temperature Interference Protons Frequency SQUID In vivo images magnetic resonance imaging nuclear magnetic resonance
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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