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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vilas Boas, D. B. Salvadori, D. M. F. Gigliotti, C. B. Monteiro, M. S. |
| Description | Country affiliation: Brazil Author Affiliation: Monteiro MS ( Laboratório de Toxicogenômica & Nutrigenômica, Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil magalysmo@gmail.com.); Vilas Boas DB ( Centro de Ciências da Saúde, Universidade Sagrado Coração, Bauru, SP, Brasil.); Gigliotti CB ( Centro de Ciências da Saúde, Universidade Sagrado Coração, Bauru, SP, Brasil.); Salvadori DM ( Laboratório de Toxicogenômica & Nutrigenômica, Departamento de Patologia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brasil.) |
| Abstract | Endometriosis is a complex disease that has both benign and malignant characteristics. It affects 5-10% of women of reproductive age. Studies have demonstrated the existence of common genetic changes in endometriosis and ovarian cancer, suggesting a possible association between these 2 diseases. However, the mechanisms that lead to the development of cancer from endometriosis remain unknown. In this study, we evaluated 3 groups of women: 72 patients with endometriosis, 70 with ovarian cancer, and 70 healthy individuals (controls). Repair (XRCC1 codons 194 and 399, XPD codons 312 and 751, and XRCC3 codon 241)- and metabolism (BLHX codon 443)-related gene polymorphisms were analyzed using the polymerase chain reaction-restriction fragment length polymorphism technique; the efficiency of DNA damage repair was analyzed in vitro in lymphocytes exposed to bleomycin. The logistic regression model was used to evaluate key associations. The results showed an increased average of chromosome breakage in bleomycin-treated lymphocytes from patients with endometriosis and ovarian cancer compared with healthy women. We also detected significant association between XRCC1, XRCC3, and BLHX polymorphisms and a high frequency of chromosomal damage. Women with endometriosis or ovarian cancer may have an altered mechanism of DNA repair, and these defects may be related to a higher incidence of ovarian cancer. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-01-28 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Chromosomal Instability Genetics Cysteine Endopeptidases Dna-binding Proteins Endometriosis Ovarian Neoplasms Genetic Association Studies Genetic Predisposition To Disease Molecular Epidemiology Epidemiology Polymorphism, Single Nucleotide Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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