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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ozugurlu, A. F. Benli, I. Katar, M. Ozyurt, H. |
| Description | Country affiliation: Turkey Author Affiliation: Katar M ( Department of Clinical Biochemistry, Faculty of Medicine, University of Gaziosmanpasa, Tokat, Turkey drkatar@hotmail.com.); Ozugurlu AF ( Department of Clinical Biochemistry, Faculty of Medicine, University of Gaziosmanpasa, Tokat, Turkey.); Ozyurt H ( Department of Clinical Biochemistry, Faculty of Medicine, University of Gaziosmanpasa, Tokat, Turkey.); Benli I ( Department of Clinical Biochemistry, Faculty of Medicine, University of Gaziosmanpasa, Tokat, Turkey.) |
| Abstract | Celiac disease (CD) is a multifactorial, inflammatory small bowel disorder characterized by nutrient malabsorption resulting from mucosal damage, the latter induced by cereal products like barley, oat, and wheat. Oxidative stress has previously been reported to play an important role in the pathogenesis of CD. In the present study, we aimed to evaluate the frequency of polymorphisms that affects the structure of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with levels being dependent on the amount of oxidative stress and whether or not there is an association with the mutations DQA1*0501, DQB1*0201, and DRB1*04 that are frequently reported for CD. SOD and GSH-Px polymorphisms were investigated by real-time quantitative polymerase chain reaction in 265 cases. Of the 117 cases that had at least one of DQA1*0501, DQB1*0201, or DRB1*04, 98 (83.75%) also had SOD enzyme polymorphisms and 68 (58.12%) also had GSH-Px polymorphisms. In conclusion, although the etiology of CD is not yet entirely clear, many mechanisms have been suggested. This study supports the notion that SOD and GSH-Px polymorphisms are involved in CD development, even though our findings were not statistically significant, and, furthermore, are influenced at various levels. SOD polymorphisms and activities were more frequently identified than those of GSH-Px. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-20 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Celiac Disease Genetics Glutathione Peroxidase Chemistry Superoxide Dismutase Adolescent Pathology Genetic Association Studies Hla-d Antigens Oxidative Stress Polymorphism, Single Nucleotide Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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