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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Feng, Y-P Deng, C-Y Wang, J. Zuo, B. Xiong, Y-Z |
| Description | Country affiliation: China Author Affiliation: Wang J ( Department of Bio-Engineering, Faculty of Environmental Engineering, Wuhan Textile University, Wuhan, Hubei Province, China.); Feng YP ( Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, China.); Zuo B ( Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, China.); Xiong YZ ( Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, China.); Deng CY ( Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Key Laboratory of Agricultural Animal Genetics and Breeding, Ministry of Education, Huazhong Agricultural University, Wuhan, Hubei Province, China wes2100@webmail.hzau.edu.cn.) |
| Abstract | The titin immunoglobulin domain (TTID) protein localizes to the Z line in muscle and binds to alpha-actinin and gamma-filamin. It plays an indispensable role in stabilizing and anchoring of thin filaments. In this study, the 5'-regulatory region of the porcine TTID gene was analyzed with bioinformatic methods. Another objective of this study was to further investigate the polymorphism in the intron 6 of the porcine TTID gene. We determined allele frequency among six Chinese porcine purebreds. The polymorphisms were genotyped in a population of 280 F2 pigs representing two Large White x Meishan reference families. Different TTID genotypes were significantly associated with carcass traits, including skin percentage (P < 0.05), loin eye area (P < 0.05), and average skin thickness (P < 0.01). Our study will continue to lay the groundwork for further investigations into the detailed function of the porcine TTID gene. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-27 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Body Composition Connectin Genetics Genetic Association Studies 5' Flanking Region Animal Husbandry Animals Gene Frequency Genotype Least-squares Analysis Molecular Sequence Data Polymorphism, Single Nucleotide Quantitative Trait Loci Swine Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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