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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Z. Z. Song, L. J. Zhang, Y. Y. Fu, X. D. Shou, J. X. Wang, X. J. |
| Description | Country affiliation: China Author Affiliation: Fu XD ( Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.); Zhang YY ( Basic Medical Sciences College of Zhengzhou University, Zhengzhou, China.); Wang XJ ( Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.); Shou JX ( Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.); Zhang ZZ ( School of Pharmacy of Zhengzhou University, Zhengzhou, China.); Song LJ ( Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China xddoccn@126.com.) |
| Abstract | Single-walled carbon nanotubes (SWCNTs) have unique transmembrane abilities. The huge superficial area and abundance of π electrons confer SWCNTs perfect absorptive capability toward proteins, nucleates, and many drugs. These characteristics make SWCNTs a new and efficient drug carrier. The purpose of this study was to disperse SWCNTs in water and have paclitaxel absorbed onto them in order to construct an asparagine-glycine-arginine (NGR)-SWCNT-Paclitaxel complex as a targeting nanoparticle system. The NGR-SWCNT-Paclitaxel complex was systematically studied, and analytical methods, including spectrophotometry for SWCNTs and high-performance liquid chromatography for paclitaxel, were employed. The preparation and the prescription of the NGR-SWCNT-Paclitaxel complex lyophilized powder were investigated. MCF-7 cancer cells, Sprague-Dawley rats, and S180 tumor-bearing mice were used as experimental subjects to evaluate the in vitro and in vivo activity of NGR-SWCNT-Paclitaxel complex dispersion. The complex dispersion showed obvious inhibition activity against MCF-7 cancer cells. Within 1 h, the NGR-SWCNT-Paclitaxel complex could be transferred to cells, and sustained the release of drugs. In addition, the tumor and liver targeting and improved therapeutic effects of the NGR-SWCNT-Paclitaxel complex were confirmed. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-03-12 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Drug Delivery Systems Nanotubes, Carbon Chemistry Paclitaxel Administration & Dosage Animals Mice Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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