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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, S. Li, Y. Liu, T. Zhang, X. F. |
| Description | Country affiliation: China Author Affiliation: Zhang XF ( Department of Breast, Liao Ning Cancer Hospital and Institute, Shenyang, China.); Liu T ( Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.); Li Y ( Department of Breast, Liao Ning Cancer Hospital and Institute, Shenyang, China.); Li S ( Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.) |
| Abstract | We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length polymorphism. We observed an increased likelihood of breast cancer patients having a higher age at menarche and first live birth, and a greater family history of breast cancer, especially among first-degree relatives. In addition, individuals with the TT genotype of MTHFR 677C/T were associated with increased risk of breast cancer by logistic regression analysis; the adjusted odds ratio (95%CI) was 3.05 (1.17-8.87). In conclusion, the results of our study indicated that the MTHFR C677T gene polymorphism could play a role in the development of breast cancer. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2015-12-09 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Alleles Breast Neoplasms Genetics Genetic Association Studies Genetic Predisposition To Disease Methylenetetrahydrofolate Reductase (nadph2) Polymorphism, Single Nucleotide Epidemiology Case-control Studies Genotype Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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