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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Garcez, W. S. Guterres, Z. R. Garcez, F. R. Duarte, C. U. N. B. D. Silva, L. M. G. E. Batista-Silva, V. F. Silva, A. F. G. |
| Description | Country affiliation: Brazil Author Affiliation: Guterres ZR ( Grupo de Estudo de Ciências Ambientais e Educação (GEAMBE), Universidade Estadual do Mato Grosso do Sul, Mundo Novo, MS, Brasil zairaguterres@yahoo.com.br.); Garcez FR ( CCET - Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.); Garcez WS ( CCET - Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.); Silva LM ( CCET - Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.); Silva AF ( Grupo de Estudo de Ciências Ambientais e Educação (GEAMBE), Universidade Estadual do Mato Grosso do Sul, Mundo Novo, MS, Brasil.); Duarte CU ( Grupo de Estudo de Ciências Ambientais e Educação (GEAMBE), Universidade Estadual do Mato Grosso do Sul, Mundo Novo, MS, Brasil.); Batista-Silva VF ( Grupo de Estudo de Ciências Ambientais e Educação (GEAMBE), Universidade Estadual do Mato Grosso do Sul, Mundo Novo, MS, Brasil.) |
| Abstract | Aiouea trinervis Meisn. is a shrub that grows in the 'Cerrado' (a savanna ecosystem) of Brazil. In this study, fractionation of ethanol extracts (EEs) from the leaves of A. trinervis led to the isolation of butanolides, namely isoobtusilactone A and obtusilactone A, as well as lignans, namely sesamin, methylpiperitol, and polyprenol-12. Their structures were determined by spectroscopic analyses. The genotoxic properties were evaluated for mutagenic and recombinogenic effects using the wing spot test (somatic mutation and recombination test, SMART) on Drosophila melanogaster. The standard and high bioactivation crosses were used. The latter cross is characterized by high sensitivity to promutagens and procarcinogens. EEs were evaluated at concentrations of 0.625, 1.25, and 2.5 mg/mL. Butanolides (isoobtusilactone A and obtusilactone A) were evaluated at concentrations of 0.1, 0.2, and 0.3 mg/mL. The results observed in both crosses were similar and indicated that EEs from the leaves of A. trinervis did not show genotoxicity at the doses that were used. However, the individuals resulting from standard and high bioactivation crosses that were treated with isoobtusilactone A and obtusilactone A showed statistically significant increases in mutant spots compared to those that were obtained in the negative control. Similar results were obtained between standard and high bioactivation crosses, indicating that butanolides had a genotoxic activity. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-19 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Drosophila Melanogaster Drug Effects Lauraceae Chemistry Lignans Toxicity Mutagenicity Tests Mutagens Plant Extracts Alkanes Animals Genetics Lactones Metabolism Recombination, Genetic Secondary Metabolism Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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