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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abebe, F. Chaudhary, J. Mandal, S. |
| Description | Country affiliation: United States Author Affiliation: Mandal S ( Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta, GA, USA.); Abebe F ( Department of Mathematics, Clark Atlanta University, Atlanta, GA, USA.); Chaudhary J ( Center for Cancer Research and Therapeutics Development, Clark Atlanta University, Atlanta, GA, USA jchaudhary@cau.edu.) |
| Abstract | Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism. The -174G>C/rs1800795 polymorphism in the IL-6 promoter is functionally relevant in terms of transcriptional regulation and disease association. We investigated a possible association of the -174G/C polymorphism with prostate cancer. Since significant racial disparities exist in prostate cancer incidence, we also investigated this association between the -174G/C polymorphism and prostate cancer in Caucasians and African-Americans, separately. Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. Sample size and power was calculated using the PGA software. We found the GG genotype to be associated with increased risk of prostate cancer in Caucasian subjects, whereas the CC genotype was associated with increased risk in the African-American sample set. Such a dimorphic genotypic association with cancer and race is unique and suggests a complex gene-gene and gene-environment interaction. |
| e-ISSN | 16765680 |
| DOI | 10.4238/2014.January.10.5 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-01-10 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Interleukin-6 Genetics Polymorphism, Single Nucleotide Promoter Regions, Genetic Prostatic Neoplasms Adolescent African Americans Case-control Studies European Continental Ancestry Group Ethnology Research Support, N.i.h., Extramural Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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