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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Qian, J. Yang, L. L. Chen, J. Zhang, L. M. Liu, Y. F. Li, W. P. |
| Description | Country affiliation: China Author Affiliation: Qian J ( Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China.); Chen J ( Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China.); Liu YF ( Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China.); Yang LL ( Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China.); Li WP ( Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China.); Zhang LM ( Laboratory for Conservation and Utilization of Bio-Resources & Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China Leminzhang8@yahoo.com.) |
| Abstract | Arabidopsis (Arabidopsis thaliana) group A1 heat shock factors (Hsfs), including HsfA1a, are important regulators in the heat shock response. Previous studies have revealed that genetically engineered HsfA1 members result in constitutive Hsf activation and heat shock protein gene (Hsp) expression under normal conditions, eventually enhancing basic thermotolerance in transgenic plants. In this study, we generated transgenic Arabidopsis plants overexpressing HsfA1a. One transgenic line showed a 94-fold increase in the level of HsfA1a mRNA (OE line 1). Overexpressing HsfA1a in OE line 1 plants resulted in higher levels of the inducible expression of Hsp18.2 and Hsp70 genes in response to heat stress, low/high pH changes, and hydrogen peroxide. Analysis of in vivo HsfA1a-promoter binding suggested that the higher level of inducible Hsp expression was mediated by stress-induced activation of elevated levels of HsfA1a in the OE plants. The OE plants showed an increase in tolerance to low/ high pH changes and hydrogen peroxide, in addition to heat shock. These results revealed that overexpressing HsfA1a had positive effects on tolerance to diverse stressors by promoting inducible Hsp expression following stress-induced HsfA1a activation. This study suggests a different mechanism for the activation of genetically engineered Hsfs from that suggested in previous reports, thus providing new insight into complex mechanisms used for achieving stress tolerance by genetic engineering. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-27 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Arabidopsis Proteins Genetics Arabidopsis Dna-binding Proteins Heat-shock Proteins Heat-shock Response Plant Proteins Transcription Factors Physiology Metabolism Gene Expression Regulation, Plant Hot Temperature Hydrogen Peroxide Pharmacology Hydrogen-ion Concentration Plants, Genetically Modified Stress, Physiological Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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