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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lin, Y. K. Liang, D. H. Xie, J. Xu, X. Han, F. Li, J. Q. Wang, K. Che, B. |
| Description | Country affiliation: China Author Affiliation: Xie J ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China.); Lin YK ( Department of Dermatology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.); Wang K ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China.); Che B ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China.); Li JQ ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China.); Xu X ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China.); Han F ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China.); Liang DH ( Department of Dermatology, Yangtze River Shipping General Hospital, Wuhan, China donghuiliangcn@163.com.) |
| Abstract | This study investigated the induced immune tolerance of autoantigen dendritic cells (imDCs) in homogenic lupus mice to support the use of dendritic cell treatment against autoimmune diseases, such as systemic lupus erythematosus. A lupus mouse was used to model based on in vitro cell culture. An immunohistochemistry assay was used to assess CD8(+), CD4(+) cell ratio in mouse spleen cells. The ratio of CD4(+)CD25(+) cells in mouse spleen lymphocytes was detected by flow cytometry, whereas the kidney was directly measured by immunofluorescence. After the injection of mouse antigen loaded bone marrow-derived antigen imDCs with a homogenetic background, mouse nucleoprotein immune with a homogenetic background was carried out. The results were compared against the simple mouse nucleoprotein immune model with a homogenic background. The 24-h urine protein, serum antinuclear antibody and anti-ds-DNA antibodies of the simple mouse model were lower compared to group S1. The CD4(+)CD25(+) cell percentage of spleen was higher in the simple mouse model compared to group S1. In the spleen, the number of lymphocyte CD8(+) cells declined, whereas the number of CD4(+) cells increased. In conclusion, after autoantigen uptake, imDCs are able to induce immune tolerance to the antigen by reinfusion, which appears to prevent or mitigate systemic lupus erythematosus-like illness. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-27 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Autoantigens Immunology Dendritic Cells Transplantation Lupus Erythematosus, Systemic Therapy Spleen Animals Cd4 Lymphocyte Count Cells, Cultured Disease Models, Animal Pathology Mice Mice, Inbred Balb C Transplantation Tolerance Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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