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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Teng, H. Wang, P. Zhang, X. Y. Li, M. S. Dong, L. M. |
| Description | Country affiliation: China Author Affiliation: Dong LM ( Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.); Zhang XY ( Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.); Teng H ( Department of Neurosurgery, The Shengjing Affiliated Hospital of China Medical University, Shenyang, China.); Li MS ( Department of Emergency Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.); Wang P ( Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, China cmu4h_wp@126.com.) |
| Abstract | We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies showed no significant association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk in comparisons of the glutamine (Gln) allele vs arginine (Arg) allele, Arg/Arg vs (Gln/Gln + Gln/Arg), Gln/Gln vs (Gln/Arg + Arg/Arg), Gln/Gln vs Arg/Arg, and Gln/Arg vs Arg/Arg [odds ratio (OR) = 0.96, 95% confidence interval (CI) = 0.80-1.16, P = 0.70; OR = 1.13, 95%CI = 0.70-1.82, P = 0.62; OR = 0.92, 95%CI = 0.79-1.07, P = 0.29; OR = 0.90, 95%CI = 0.69-1.16, P = 0.42; OR = 0.89, 95%CI = 0.75-1.05, P = 0.17, respectively]. In subgroup analysis by ethnicity, no association was observed between the XRCC1 Arg399Gln polymorphism and bladder cancer risk in Caucasian, Mongoloid, or black populations. We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-11-28 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Dna-binding Proteins Genetics Genetic Association Studies Genetic Predisposition To Disease Polymorphism, Single Nucleotide Urinary Bladder Neoplasms Alleles Gene Frequency Genetic Heterogeneity Publication Bias Risk Factors Meta-analysis Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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