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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bayaer, N. Gu, Y. Yue, M. Hu, Q. Tian, Y. G. Wang, Y. J. Gu, W. W. |
| Spatial Coverage | Tibet |
| Description | Country affiliation: China Author Affiliation: Yue M ( Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China.); Tian YG ( Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China.); Wang YJ ( Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China.); Gu Y ( Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China.); Bayaer N ( Songshan Lake Pearl Laboratory Animal Science & Technology Co., Ltd., Dongguan, China.); Hu Q ( Songshan Lake Pearl Laboratory Animal Science & Technology Co., Ltd., Dongguan, China.); Gu WW ( Department of Laboratory Animal Center, Southern Medical University, Guangzhou, China weiwanggu@126.com.) |
| Abstract | The IGF-1 gene is an important regulating factor that has a growth-promoting effect on growth hormone. The IGF-1 gene promotes muscle cell differentiation in the muscle cell formation process. The IGF-1 gene also regulates the growth of skeletal muscle during skeletal muscle growth. In addition, the IGF-1 gene plays an important role in the formation of mammals and poultry embryos, and the process of postnatal growth. The IGF-1 gene has been implicated as a candidate gene for the regulation of pig growth traits. We analyzed exon 3 of the IGF-1 gene polymorphism in Tibetan miniature pigs (N = 128) by polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing. One single nucleotide polymorphism (T40C) was found on exon 3 of the IGF-1 gene. Statistical analysis of genotype frequencies revealed that the T allele was dominant in Tibetan miniature pigs at the T40C locus. The association analysis showed that the IGF-1 mutation had an effect on the body weight, body length, and chest circumference of pigs aged 6-8 months. In addition, the IGF-1 mutation had an effect on body weight in pigs aged 9-11 months (P < 0.05). We speculated that the pigs with the TT genotype grow more rapidly compared to those with the TC genotype. The TC genotype of the Tibetan miniature pig has a smaller body type. This information provides a theoretical basis for the genetic background of Tibetan miniature pigs. |
| e-ISSN | 16765680 |
| Journal | Genetics and Molecular Research |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date | 2014-02-27 |
| Publisher Place | Brazil |
| Access Restriction | Open |
| Subject Keyword | Insulin-like Growth Factor I Genetics Polymorphism, Single Nucleotide Swine, Miniature Growth & Development Animals Body Size Breeding Exons Genetic Association Studies Genotype Species Specificity Swine Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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