| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Zhang, S. N. Liu, Y. L. Zhang, R. Tan, J. P. Cai, W. B. Gao, L. Chen, H. Chen, L. B. Zhang, J. P. Wang, Y. H. Liu, M. L. Meng, L. L. |
| Description |
Country affiliation: China Author Affiliation: Gao L ( Department of Clinical Laboratory, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.); Zhang JP ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Chen H ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Zhang SN ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Chen LB ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Tan JP ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Liu ML ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Meng LL ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Wang YH ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Zhang R ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Liu YL ( Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.); Cai WB ( Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou, China weibincai@163.com.) |
| Abstract |
To investigate the characteristics of immune cells before and after immunotherapy and their clinical significance in patients with unexplained recurrent spontaneous abortion (URSA), an analysis of 67 URSA patients, 67 sporadic spontaneous abortion (SA) patients, and 22 normal nonpregnant women (as controls) was conducted. URSA patients underwent immunotherapy using paternal lymphocytes. Peripheral blood from patients and controls was examined for lymphocytes and other markers of immune status. Before the immunotherapy, lymphocyte counts, CD4:CD8 cell ratios, and the relative proportion of natural killer (NK) cells were significantly higher in the URSA patient group than in the SA patient and control groups (P < 0.05). After the therapy, all of these three measures were decreased, whereas the percentage of T cells was increased, and statistically significant differences before and after the immunotherapy were detected (P < 0.05). Therefore, the immune system appears to be activated in the URSA patients, and the abnormal immunologic state in the URSA patients is more severe than in the SA patients. The alterations in T and NK cells may be involved in the etiopathogenesis of URSA. Lymphocyte immunotherapy appears to be an effective treatment for URSA patients. |
| e-ISSN |
16765680 |
| Journal |
Genetics and Molecular Research |
| Issue Number |
1 |
| Volume Number |
13 |
| Language |
English |
| Publisher |
Fundação de Pesquisas Científicas de Ribeirão Preto |
| Publisher Date |
2014-02-27 |
| Publisher Place |
Brazil |
| Access Restriction |
Open |
| Subject Keyword |
Abortion, Spontaneous Immunology Physiopathology Killer Cells, Natural Metabolism T-lymphocytes Therapy Cd4-cd8 Ratio Case-control Studies Immunotherapy Pregnancy Pregnancy Outcome Research Support, Non-u.s. Gov't Discipline Genetics Discipline Molecular Biology Discipline Bioinformatics |
| Content Type |
Text |
| Resource Type |
Article |
